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Francisco Javier Cubero Selected Research

Mitogen-Activated Protein Kinase 8

12/2021Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease.
6/2020Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma.

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Francisco Javier Cubero Research Topics

Disease

10Liver Cirrhosis (Hepatic Cirrhosis)
12/2021 - 05/2009
9Fibrosis (Cirrhosis)
12/2021 - 05/2009
8Neoplasms (Cancer)
01/2022 - 01/2017
8Hepatocellular Carcinoma (Hepatoma)
12/2021 - 12/2012
6Liver Diseases (Liver Disease)
04/2022 - 01/2014
6Carcinogenesis
01/2021 - 05/2011
5Fatty Liver
01/2022 - 06/2013
5Cholangiocarcinoma
12/2021 - 01/2019
4Chemical and Drug Induced Liver Injury
04/2022 - 09/2014
4Inflammation (Inflammations)
12/2021 - 06/2013
4Acute Liver Failure (Fulminant Hepatic Failure)
10/2021 - 04/2016
3Mitochondrial Diseases (Mitochondrial Disease)
04/2022 - 04/2018
3Cholestasis
01/2021 - 12/2018
3Hepatitis
11/2020 - 12/2012
3Insulin Resistance
01/2020 - 06/2010
2Non-alcoholic Fatty Liver Disease
01/2022 - 01/2017
2Pathologic Constriction (Stenosis)
01/2022 - 06/2020
2Liver Neoplasms (Liver Cancer)
01/2019 - 09/2017
2Alcoholic Liver Diseases (Alcoholic Liver Disease)
07/2012 - 12/2008
1Celiac Disease (Celiac Sprue)
01/2022
1Cysts
12/2021
1Glucose Intolerance
09/2021
1Hepatomegaly
06/2021
1Infections
03/2021
1COVID-19
01/2021
1Acute Kidney Injury (Acute Renal Failure)
01/2021
1Fibrosarcoma
06/2020
1Retinoblastoma (Glioblastoma, Retinal)
01/2019
1Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2019
1Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
12/2018
1Alcoholic Fatty Liver
10/2017
1Hepatic Encephalopathy
12/2016
1Autoimmune Hepatitis
04/2016

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
01/2022 - 09/2014
6Biomarkers (Surrogate Marker)IBA
03/2021 - 05/2009
5CytokinesIBA
06/2020 - 12/2012
4Reactive Oxygen Species (Oxygen Radicals)IBA
04/2018 - 05/2009
3Acetaminophen (Paracetamol)FDA LinkGeneric
04/2022 - 04/2016
3Bile Acids and Salts (Bile Acids)IBA
01/2022 - 01/2020
3CollagenIBA
12/2021 - 07/2014
3Phosphotransferases (Kinase)IBA
06/2020 - 06/2010
3Death Domain ReceptorsIBA
12/2018 - 12/2012
3Caspase 8 (Caspase-8)IBA
12/2018 - 06/2013
3Ethanol (Ethyl Alcohol)IBA
09/2017 - 12/2008
2Methionine (L-Methionine)FDA Link
04/2022 - 01/2017
2Mitogen-Activated Protein Kinase 8IBA
12/2021 - 06/2020
2Pharmaceutical PreparationsIBA
10/2021 - 03/2021
2Alanine Transaminase (SGPT)IBA
06/2021 - 06/2013
2DNA (Deoxyribonucleic Acid)IBA
03/2021 - 01/2021
2LipidsIBA
11/2020 - 06/2020
2NF-kappa B (NF-kB)IBA
06/2020 - 01/2014
2ErbB Receptors (EGF Receptor)IBA
06/2020 - 05/2011
2Transcription Factors (Transcription Factor)IBA
01/2020 - 01/2017
2Arachidonic Acid (Vitamin F)IBA
07/2012 - 12/2008
2Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
07/2012 - 12/2008
1S-Adenosylmethionine (Ademetionine)IBA
04/2022
1Glycine N-Methyltransferase (Glycine Sarcosine N-Methyltransferase)IBA
04/2022
1AmmoniaIBA
04/2022
1Glutathione (Reduced Glutathione)IBA
04/2022
1Cell-Free Nucleic AcidsIBA
01/2022
1Triglycerides (Triacylglycerol)IBA
12/2021
1Thioacetamide (Thioacetamid)IBA
12/2021
1TunicamycinIBA
12/2021
1Transaminases (Aminotransferases)IBA
09/2021
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
06/2021
1RNA (Ribonucleic Acid)IBA
06/2021
1GTP-Binding Proteins (G-Protein)IBA
03/2021
1Histones (Histone)IBA
01/2021
1Small Interfering RNA (siRNA)IBA
11/2020
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
06/2020
1Interleukin-6 (Interleukin 6)IBA
06/2020
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
06/2020
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2020
1CholesterolIBA
01/2020
1AdiponectinIBA
01/2019
1Mitogen-Activated Protein KinasesIBA
01/2019
1Type I Tumor Necrosis Factor ReceptorsIBA
01/2019
1AMP-Activated Protein KinasesIBA
01/2019
1AdipokinesIBA
01/2019
1Caspase 3 (Caspase-3)IBA
12/2018
1CaspasesIBA
12/2018
1Cyclin-Dependent Kinase 2IBA
11/2018
1CyclinsIBA
11/2018
1Analgesics (Analgesic Drugs)IBA
04/2018
1MicroRNAs (MicroRNA)IBA
01/2018
1Chemokine CCL5IBA
01/2017
1Interleukin-17 (Interleukin 17)IBA
01/2017
1Choline (Choline Chloride)IBA
01/2017
1Cyclic AMP Response Element ModulatorIBA
01/2017
1CreatinineIBA
12/2016
1Phenprocoumon (Liquamar)FDA Link
04/2016
1Protein Kinases (Protein Kinase)IBA
04/2016

Therapy/Procedure

8Therapeutics
04/2022 - 06/2013
3Liver Transplantation
10/2021 - 01/2014
2Ligation
01/2021 - 07/2014
2Precision Medicine
11/2020 - 02/2020
2Hepatectomy
01/2019 - 12/2012
1Artificial Respiration (Mechanical Ventilation)
01/2021
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2017
1Injections
04/2016